Pyridonecarboxylic acids as antibacterial agents. VII. Synthesis and structure-activity relationship of amino- and hydroxyl-substituted 7-cycloalkyl and 7-vinyl derivatives of 1-cyclopropyl-6-fluoro-4-quinolone-3-carboxylic acid

DOI: 10.1248/cpb.42.2055

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2055 - 2062 (1994)

Update date:2022-07-30

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Authors:

Todo Todo

Nitta Nitta

Miyajima

Fukuoka Fukuoka

Ikeda Ikeda

Yamashiro

Saikawa Saikawa

Narita Narita

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Article abstract of DOI:10.1248/cpb.42.2055

Novel C(7)-derivatives of 1-cyclopropyl-6-fluoro-4-quinolone carboxylic acid (3a-o) have been synthesized and evaluated for in vitro antibacterial activity. Compounds 3e (3-aminocyclobutyl), 3g (1-aminocyclopropyl), 3m ((2-aminomethyl)vinyl), and 3o ((1-a

Full text of DOI:10.1248/cpb.42.2055

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