Highly Stereocontrolled Sequential Asymmetric Michael Addition Reactions with Cinnamate Esters - Generation of Three and Four Contiguous Stereogenic Centers on Seven-Carbon Acyclic Motifs

DOI: 10.1016/S0040-4039(00)78330-4

Source and publish data:

Tetrahedron Letters p. 7509 - 7512 (1994)

Update date:2022-08-04

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Authors:

Hanessian, Stephen

Gomtsiyan, Arthur

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Article abstract of DOI:10.1016/S0040-4039(00)78330-4

The reaction of allyl and crotyl bicyclic chiral phosphonamide anions with two cinnamate esters leads to a sequential Michael reaction with excellent diastereoselectivity.The option to quench enolates with methyl iodide greatly enhances the versatility of

Full text of DOI:10.1016/S0040-4039(00)78330-4

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