Highly Stereocontrolled Sequential Asymmetric Michael Addition Reactions with Cinnamate Esters - Generation of Three and Four Contiguous Stereogenic Centers on Seven-Carbon Acyclic Motifs

Article abstract of DOI:10.1016/S0040-4039(00)78330-4

The reaction of allyl and crotyl bicyclic chiral phosphonamide anions with two cinnamate esters leads to a sequential Michael reaction with excellent diastereoselectivity.The option to quench enolates with methyl iodide greatly enhances the versatility of