A new synthetic route to isoquinolin-1(2H)-one derivatives from 3-hydroxyphthalides

Article abstract of DOI:10.1055/s-1995-3927

A new synthetic route for the conversion of substituted 3-hydroxyphthalides into the corresponding isoquinolin-1(2H)-one was established. This method can be applied to the preparation of isoquinolin-1(2H)-ones with electron-withdrawing groups that are relatively difficult to synthesize by conventional procedures.