Tricyclic Heteroaromatic Systems. Synthesis and A1 and A2a Adenosine Binding Activities of Some 1-Aryl-1,4-dihydro-3-methylbenzopyranopyrazol-4-ones, 1-Aryl-4,9-dihydro-3-methyl-1H-pyrazoloquinolin-4-ones, and 1-Aryl-1H-imidazoquinoxalines

Article abstract of DOI:10.1021/jm00008a011

The syntheses and A₁ and A_2a adenosine binding activities of some new 1-aryl-1,4-dihydro-3-methyl<1>benzopyrano<2,3-c>pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo<3,4-b>quinolin-4-ones, and 1-aryl-1H-imidazo<4,5-b>quinoxalines are reported.Some compounds show A₁ adenosine receptor affinity and selectivity.Structure-activity relationships on these new classes of adenosine receptor ligands are defined.