Synthesis p. 1446 - 1450 (1997)
Update date:2022-07-30
Akama, Tsutomu
Ueno, Kimihisa
Saito, Hiromitsu
Kasai, Masaji
The multigram scale synthesis of 4',5-diamino-3'6,8-trifluoroflavone, a potent antitumor agent, is described in which regioselective introduction of a carbonyl group into the ortho-position to the amide group of 2-[2,4-difluoro-5-(pivaloylamino)phenyoxy]tetrahydropyran is achieved by using sequential direct ortho-metalations as the key step.
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Doi:10.1016/S0040-4039(00)78346-8
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(1997)Doi:10.1021/jo9810359
(1998)