Synthesis p. 1446 - 1450 (1997)
Update date:2022-07-30
Akama, Tsutomu
Ueno, Kimihisa
Saito, Hiromitsu
Kasai, Masaji
The multigram scale synthesis of 4',5-diamino-3'6,8-trifluoroflavone, a potent antitumor agent, is described in which regioselective introduction of a carbonyl group into the ortho-position to the amide group of 2-[2,4-difluoro-5-(pivaloylamino)phenyoxy]tetrahydropyran is achieved by using sequential direct ortho-metalations as the key step.
View MoreShanghai Goyic Pharmaceutical&Chemical Co,. Ltd
Contact:+86-021-60275964
Address:No. 528 ruiqing road
Contact:
Address:No.89,Xinhua Road, Langfang City,Hebei China
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Xinchang Jiu Xin Pharmaceutical Co., Ltd
website:http://www.jiuxinpharm.com
Contact:86 137 5756 8585
Address:Poyang industry Park
ZHEJIANG CHEMICAL INDUSTRY INSTITUTE TECHNOLOGY CO.,LTD(expird)
Contact:86-575-82730298
Address:shangyu
Doi:10.1016/S0040-4039(00)78346-8
(1994)Doi:10.1007/BF01165021
(1994)Doi:10.1016/S0040-4020(01)89360-1
(1994)Doi:10.1002/zaac.19562830109
(1956)Doi:10.1016/S0008-6215(97)00131-6
(1997)Doi:10.1021/jo9810359
(1998)