Synthesis of 5-arylpyrrolo[2,1-a]isoquinolin-3(2H)-ones from N-phenethylsuccinimides and organolithium reagents

Article abstract of DOI:10.1016/0040-4020(95)00154-Z

The 5-aryl-8,9-dialkoxypyrrolo[2,1-a]isoquinolin-3-(2H)-ones 1 and 2, which can be considered as 3-arylisoquinoline derivatives, can be efficiently prepared by reaction of the N-1,2-bis[3,4-dimethoxyphehyl)ethylsuccinimides 3 with organolithium reagents,