Enantio- and diastereodivergent synthesis of all four diastereomers of the 2,6-disubstituted 3-piperidinol chiral building block

Article abstract of DOI:10.1016/0040-4039(95)00661-U

Enantio- and diastereodivergent synthesis of all four diastereomers of 2,6-disubstituted 3-piperidinol has been achieved. The versatility of these compounds as the chiral building block for alkaloid synthesis has been demonstrated both by total synthesis of iso-6-cassine and by formal synthesis of prosopinine, cassine, and spectaline.