Stereocontrolled Synthesis of R or S Diphenylphosphinoyl Hydroxy Aldehydes and 1,2-Diols Using Bicyclic Aminals

DOI: 10.1016/0040-4039(95)00334-9

Source and publish data:

Tetrahedron Letters p. 2681 - 2684 (1995)

Update date:2022-08-03

Topics:

Authors:

O'Brien, Peter

Warren, Stuart

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Article abstract of DOI:10.1016/0040-4039(95)00334-9

Homochiral diphenylphosphinoyl hydroxy aldehydes 1 and 2 have been made by diastereoselective additions of metallated methyldiphenylphosphine oxides 10 to Mukaiyama's keto aminals 8 and 9.Reduction to diphenylphosphinoyl 1,2 diols 3 and 4 is also described.Sharpless asymmetric dihydroxylation provides an alternative route diphenylphosphinoyl 1,2 diols 3 and 4, the two approaches are compared.

Full text of DOI:10.1016/0040-4039(95)00334-9

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