SOLID PHASE SYNTHESIS OF DIRECTLY LINKED PEPTIDE-OLIGODEOXYNUCLEOTIDE HYBRIDS USING STANDARD SYNTHESIS PROTOCOLS

Article abstract of DOI:10.1016/0040-4039(95)00155-6

We desribed a general methodology for the solid phase synthesis of directly linked peptide-oligonucleotide hybrids using a sarcosine-modified controlled pore glass (CPG) support and employing phosphoramidite chemistry for the oligonucleotide synthesis and