Replacement of the nonperoxidic trioxane oxygen atom of artemisinin by carbon: Total synthesis of (+)-13-carbaartemisinin and related structures

Article abstract of DOI:10.1016/0040-4039(95)00689-A

Provided by total synthesis, endoperoxides 17, 19 and 21 underwent intramolecular oxymercuration-demercuration leading respectively to formation of an isomeric tetracycle, (1aS,3S,5aS,6R,8aS,9R,12S)-10-deoxo-13-carbaartemisinin 18, (+)-10-deoxo-13-carbaar