Synthesis, Structure Elucidation, and Biochemical Evaluation of 7α- and 7β-Arylaliphatic-Substituted Androst-4-ene-3,17-diones as Inhibitors of Aromatase

DOI: 10.1021/jm00015a006

Source and publish data:

Journal of Medicinal Chemistry p. 2842 - 2850 (1995)

Update date:2022-08-04

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Authors:

O'Reilly, Jill M.

Li, Naiyin

Duax, William L.

Brueggemeier, Robert W.

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Article abstract of DOI:10.1021/jm00015a006

The inhibition of aromatase, the cytochrome P450 enzyme complex responsible for the conversion of androgens to estrogens, may be useful for the endocrine treatment of breast cancer.Previously, several 7α-thio-substituted androstenediones have been shown t

Full text of DOI:10.1021/jm00015a006

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