Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-Oxetanones with a meta-substituent on the benzene ring in the side chain

DOI: 10.1248/cpb.42.1272

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1272 - 1278 (1994)

Update date:2022-08-05

Topics:

Authors:

Hashizume

Ito Ito

Kanaya Kanaya

Nagashima

Usui Usui

Oshima Oshima

Kanao Kanao

Tomoda Tomoda

Sunazuka

Kumagai Kumagai

Omura Omura

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Article abstract of DOI:10.1248/cpb.42.1272

Isosteric side chain analogs of 3a were synthesized and tested for inhibitory activities towards 3-hydroxy-3-methylglutaryl coenzyme A (HMG- CoA) synthase and upon cholesterol production in Hep G2 cells and in mouse liver. It became clear that the lipophi

Full text of DOI:10.1248/cpb.42.1272

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