Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-Oxetanones with a meta-substituent on the benzene ring in the side chain

DOI: 10.1248/cpb.42.1272

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1272 - 1278 (1994)

Update date:2022-08-05

Topics:

Authors:

Hashizume

Ito Ito

Kanaya Kanaya

Nagashima

Usui Usui

Oshima Oshima

Kanao Kanao

Tomoda Tomoda

Sunazuka

Kumagai Kumagai

Omura Omura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.1272

Isosteric side chain analogs of 3a were synthesized and tested for inhibitory activities towards 3-hydroxy-3-methylglutaryl coenzyme A (HMG- CoA) synthase and upon cholesterol production in Hep G2 cells and in mouse liver. It became clear that the lipophi

Full text of DOI:10.1248/cpb.42.1272

NII-Electronic Library Service

Products guided by the article

Product name:3-<3-(2-tetrahydropyranyloxy)propyl>benzoic acid

Cas No:167147-65-1

R&D Labs maybe for 167147-65-1

jiangsu senxuan pharmaceutical and chemical co.,ltd

Contact:86-523-87982810

Address:hongqiao industrial zone,taixing,jiangsu china
Huayang chemical Co., LTD

Contact:+86-18653358619

Address:zibo
Jiaxing Barton Chemicals

website:http://www.chinabarton.com

Contact:+86-573-82719618

Address:No. 162 Fumin Road, Honghe Town,
Santow Laboratory Limited

Contact:+86-371-55981030

Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building

Relevant to this article

Insertion of Mercury into Iron-Halogen Bonds. X-Ray Structure of <(p-MeC6H4NC)5Fe->HgI2>

Doi:10.1039/DT9910002503
(1991)
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2

Doi:10.1016/j.bmc.2012.03.044
(2012)
A simple chiral recognition system to investigate substituent effects on π-π Interactions

Doi:10.1021/ol3014057
(2012)
Pyrrole Mannich bases as potential antipsychotic agents

Doi:10.1021/jm00081a018
(1992)
Angular-shaped naphthodifurans, naphtho[1,2-b;5,6-b′]- and naphtho[2,1-b;6,5-b′]-difuran: Are they isoelectronic with chrysene?

Doi:10.1039/c2cc31546g
(2012)
Highly homogeneous stereocontrolled construction of quaternary hydroxyesters by addition of dimethylzinc to α-ketoesters promoted by chiral perhydrobenzoxazines and B(OEt)₃

Doi:10.1002/chem.201102913
(2012)

Article Doi