4,10-Dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10- dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists

Article abstract of DOI:10.1016/S0960-894X(99)00278-4

Synthesis and structure-activity relationships (SAR) of arginine vasopressin receptor (AVP) antagonists are described. Potent and orally active compounds are prepared when tricyclic 10,11-dihydro-5H-pyrrolo[2,1- c][1,4]benzodiazepine moiety in VPA-985 1 i