Bioorganic and Medicinal Chemistry Letters p. 1365 - 1370 (1997)
Update date:2022-07-31
Topics:
Smallheer, Joanne M.
McHugh, Robert J.
Chang, Chong-Hwan
Kaltenbach III, Robert F.
Worley, Tabitha V.
Klabe, Ronald M.
Bacheler, Lee T.
Rayner, Marlene M.
Erickson-Viitanen, Susan
Seitz, Steven P.
A series of analogs of HIV protease inhibitor DMP323 containing functionalized aliphatic P2/P2' groups was prepared and evaluated for HIV protease inhibition and antiviral activity in a cell-based assay. Asymmetric compounds with a 5-hydroxypentyl substituent at P2 and a benzylic substituent at P2' showed increased potency over the corresponding symmetrically substituted analogs.
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