Bioorganic and Medicinal Chemistry Letters p. 1365 - 1370 (1997)
Update date:2022-07-31
Topics:
Smallheer, Joanne M.
McHugh, Robert J.
Chang, Chong-Hwan
Kaltenbach III, Robert F.
Worley, Tabitha V.
Klabe, Ronald M.
Bacheler, Lee T.
Rayner, Marlene M.
Erickson-Viitanen, Susan
Seitz, Steven P.
A series of analogs of HIV protease inhibitor DMP323 containing functionalized aliphatic P2/P2' groups was prepared and evaluated for HIV protease inhibition and antiviral activity in a cell-based assay. Asymmetric compounds with a 5-hydroxypentyl substituent at P2 and a benzylic substituent at P2' showed increased potency over the corresponding symmetrically substituted analogs.
View MoreLandz International Company Ltd.
Contact:0086-21-58891610
Address:985 Dongfang Road, Pudong, Shanghai 200122 China
Hangzhou Donglou Bio-nutrient Co., Ltd.
Contact:+86-571-82225795,13967112289
Address:Louta Town, Xiaoshan,Hangzhou,Zhejiang
RongCheng K&S Chemical Co.,Ltd
Contact:0631-7336369
Address:rongcheng ,shandong province china
Lyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Shanghai Synmedia Chemical Co., Ltd
Contact:+86-21-38681880
Address:6th Floor, 11A Building, No.528 Ruiqing Road, Heqing town, Pudong new district, Shanghai China
Doi:10.1016/0040-4039(95)00093-R
(1995)Doi:10.1007/BF01176036
()Doi:10.1016/00404-0399(50)0993M-
(1995)Doi:10.1016/00404-0399(50)1100V-
(1995)Doi:10.1016/0040-4020(95)00224-V
(1995)Doi:10.1016/0040-4020(95)00350-H
(1995)
