
Bioorganic and Medicinal Chemistry Letters p. 1613 - 1618 (1999)
Update date:2022-08-02
Topics:
Basarab, Gregory S.
Jordan, Douglas B.
Gehret, Troy C.
Schwartz, Rand S.
Wawrzak, Zdzislaw
Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.
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