Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Article abstract of DOI:10.1016/S0960-894X(99)00247-4

Five X-ray crystal structures of scytalone dehydratase complexed with different inhibitors have delineated conformationally flexible regions of the binding pocket. This information was used for the design and synthesis of a norephedrine-derived cyanoacetamide class of inhibitors leading to potent fungicides.