Novel and potent adenosine 3',5'-cyclic phosphate phosphodiesterase III inhibitors: Thiazolo[4,5-b][1,6]naphthyridin-2-ones

Article abstract of DOI:10.1021/jm00014a007

The transformation of 3-bromo-1,6-naphthyridin-2(1H)-ones 8 to thiazolo[4,5-b][1,6]naphthyridin-2(1H)-ones 12 resulted in a 2-9-fold increase in cAMP phosphodiesterase (PDE) III inhibitory potency. Unlike the secondary binding sites on the cAMP PDE III is