Tetrahedron p. 8459 - 8470 (1995)
Update date:2022-08-04
Topics:
Scherkenbeck, Juergen
Plant, Andrew
Harder, Achim
Mencke, Norbert
The potent anthelmintic cyclooctadepsipeptide PF1022A was synthesized by a series of fragment condensations starting from the known (S)-2-chloropropanoic acid and (S)-2-chloro-3-phenylpropanoic acid in eleven steps with a total yield of 13percent.Noteworthy is the excellent yield of the BOP-Cl mediated lactamization reaction of the linear precursor 17 leading to the 24-membered macrocycle.
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