A Highly Efficient Synthesis of the Anthelmintic Cyclooctadepsipeptide PF1022A

Article abstract of DOI:10.1016/0040-4020(95)00461-G

The potent anthelmintic cyclooctadepsipeptide PF1022A was synthesized by a series of fragment condensations starting from the known (S)-2-chloropropanoic acid and (S)-2-chloro-3-phenylpropanoic acid in eleven steps with a total yield of 13percent.Noteworthy is the excellent yield of the BOP-Cl mediated lactamization reaction of the linear precursor 17 leading to the 24-membered macrocycle.