Synthetic studies on bryostatins, potent antineoplastic agents: Synthesis of the C17-C;27 fragment of C20 deoxybryostatins

Article abstract of DOI:10.1016/0040-4039(95)01309-6

Synthetic process toward the bottom-half portion of C₂₀ deoxygenated series of bryostatins is described. It is noted that the neighboring group participation consisting of a six-membered ring enabled introduction of an unsaturated bond required for the characteristic α,β-unsaturated ester of the bryostatins.