Bioorganic and Medicinal Chemistry Letters p. 1915 - 1920 (1999)
Update date:2022-08-05
Topics:
Moe, Scott T.
Shimizu, Scot M.
Smith, Daryl L.
Van Wagenen, Bradford C.
DelMar, Eric G.
Balandrin, Manuel F.
Chien, Yongwei Eric
Raszkiewicz, Joanna L.
Artman, Linda D.
Mueller, Alan L.
Lobkovsky, Emil
Clardy, Jon
The synthesis, biological activity, and single crystal X-ray structure of NPS 1392, (R)-(-)-3,3-bis(3-fluorophenyl)-2-methylpropan-1-amine (3a), a potent, stereoselective antagonist of the NMDA receptor, are described. The NMDA receptor selectively bound
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