Synthesis, biological activity, and absolute stereochemical assignment of NPS 1392: A potent and stereoselective NMDA receptor antagonist

DOI: 10.1016/S0960-894X(99)00317-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1915 - 1920 (1999)

Update date:2022-08-05

Topics:

Authors:

Moe, Scott T.

Shimizu, Scot M.

Smith, Daryl L.

Van Wagenen, Bradford C.

DelMar, Eric G.

Balandrin, Manuel F.

Chien, Yongwei Eric

Raszkiewicz, Joanna L.

Artman, Linda D.

Mueller, Alan L.

Lobkovsky, Emil

Clardy, Jon

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Article abstract of DOI:10.1016/S0960-894X(99)00317-0

The synthesis, biological activity, and single crystal X-ray structure of NPS 1392, (R)-(-)-3,3-bis(3-fluorophenyl)-2-methylpropan-1-amine (3a), a potent, stereoselective antagonist of the NMDA receptor, are described. The NMDA receptor selectively bound

Full text of DOI:10.1016/S0960-894X(99)00317-0

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