A route to homochiral (S)-O-methyl mandelic acid and related α-alkoxy carboxylic acids from isopropylidene glycerol

Article abstract of DOI:10.1080/00397919508011831

An improved synthesis of the useful ketones 7 is described. These ketones are then further modified via a highly stereospecific reduction to give homochiral α-alkoxy carboxylic acids which are useful chiral auxiliaries and intermediates.

Full text of DOI:10.1080/00397919508011831

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Synthetic Communications: An
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Organic Chemistry
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A Route to Homochiral (S)-
O-Methyl Mandelic Acid and
Related α-Alkoxy Carboxylic
Acids from Isopropylidene
Glycerol
Sheetal Handa a , John E. Hawes b & Robert J. Pryce
b
a Department of Chemistry, King's College London,
Strand, London, WC2R 2LS, England
b Shell Research Centre, Sittingbourne, Kent, ME9
8AG, England
Published online: 16 Feb 2007.
To cite this article: Sheetal Handa , John E. Hawes & Robert J. Pryce (1995): A Route
to Homochiral (S)-O-Methyl Mandelic Acid and Related α-Alkoxy Carboxylic Acids
from Isopropylidene Glycerol, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 25:18, 2837-2845
To link to this article: http://dx.doi.org/10.1080/00397919508011831
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