3'-Deoxy-3'-(vinylsulphonyl)thymidine - A New Reactive Analogue of AZT: Its Synthesis and Reactivities Towards Various Nucleophiles

Article abstract of DOI:10.1016/0040-4020(95)00403-U

A reactive triatomic analogue of AZT, 3'-deoxy-3'-(vinylsulphonyl)thymidine has been synthesised from easily accessible starting material.The vinyl-sulphone nucleoside was reacted with a variety of nucleophiles to generate new classes of modified nucleosides where the functional groups were attached to the C-3' of a nucleoside through flexible ethyl sulphone spacer.