Tetrahedron p. 7857 - 7866 (1995)
Update date:2022-07-29
Topics:
Bera, Sanjib
Sakthivel, Kandasamy
Pathak, Tanmaya
Langley, Graham J.
A reactive triatomic analogue of AZT, 3'-deoxy-3'-(vinylsulphonyl)thymidine has been synthesised from easily accessible starting material.The vinyl-sulphone nucleoside was reacted with a variety of nucleophiles to generate new classes of modified nucleosides where the functional groups were attached to the C-3' of a nucleoside through flexible ethyl sulphone spacer.
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