3'-Deoxy-3'-(vinylsulphonyl)thymidine - A New Reactive Analogue of AZT: Its Synthesis and Reactivities Towards Various Nucleophiles

DOI: 10.1016/0040-4020(95)00403-U

Source and publish data:

Tetrahedron p. 7857 - 7866 (1995)

Update date:2022-07-29

Topics:

Authors:

Bera, Sanjib

Sakthivel, Kandasamy

Pathak, Tanmaya

Langley, Graham J.

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Article abstract of DOI:10.1016/0040-4020(95)00403-U

A reactive triatomic analogue of AZT, 3'-deoxy-3'-(vinylsulphonyl)thymidine has been synthesised from easily accessible starting material.The vinyl-sulphone nucleoside was reacted with a variety of nucleophiles to generate new classes of modified nucleosides where the functional groups were attached to the C-3' of a nucleoside through flexible ethyl sulphone spacer.

Full text of DOI:10.1016/0040-4020(95)00403-U

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