3-Alkylated indoles by reduction of sulfonyl indoles under flow chemical conditions

Article abstract of DOI:10.24820/ark.5550190.p010.882

Reduction of 3-(1-arylsulfonylalkyl) indoles (sulfonyl indoles) using polymer-supported sodium borohydride under flow chemical conditions allows an efficient synthesis of 3-alkylindoles with a notable waste minimization and reduced solvent consumption. Th

Full text of DOI:10.24820/ark.5550190.p010.882

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3-Alkylated indoles by reduction of sulfonyl indoles under flow chemical
conditions
Elena Chiurchiù, Alessandro Palmieri,* and Marino Petrini*
School of Science and Technology, Chemistry Division, Università di Camerino, via S. Agostino, 1
I-62032 Camerino, Italy
Email: alessandro.palmieri@unicam.it, marino.petrini@unicam.it
Dedicated to Professor Stephen Hanessian in recognition of his contribution to organic synthesis
Received 01-18-2019
Accepted 03-07-2019
Published on line 03-12-2019
Abstract
Reduction of 3-(1-arylsulfonylalkyl) indoles (sulfonyl indoles) using polymer-supported sodium borohydride
under flow chemical conditions allows an efficient synthesis of 3-alkylindoles with a notable waste
minimization and reduced solvent consumption. The flow conditions can be also applied to the synthesis of
sulfonyl indoles which can be obtained by a three-component coupling of indoles with aldehydes and p-
toluenesulfinic acid. Using the two-step flow chemical approach, 3-alkylindoles can be directly obtained from
their remote indole and aldehyde precursors.
Keywords: Alkylation, flow chemistry, one-pot process, reduction, sulfonyl indoles
DOI: https://doi.org/10.24820/ark.5550190.p010.882
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Introduction
Indole functionalization by electrophilic substitution is a widespreadly used approach to introduce simple or
functionalized frameworks in this heteroaromatic system. Friedel–Crafts (F–C) based procedures usually
involve the utilization of various reagents such as acyl halides or electron-poor olefins which electrophilic
character can be suitably enhanced by Brønsted or Lewis acid catalysis.1-5 Alkylation of indoles exploiting the
classical F–C conditions is usually hampered by the known limitations pertaining to many electron rich
heterocyclic derivatives.6 The direct utilization of alkyl halides in acid catalyzed procedures is featured by
moderate yields and formation of variable amount of bisalkylated derivatives.7 Electrophilic addition of
unsaturated derivatives such as terminal alkynes to indoles can be used for the preparation of 3-alkylindoles.
In one of these protocols the alkenylindole preliminarily formed upon the In(III)-catalyzed F–C reaction of the
alkyne with the indole is reduced by diphenylmethylsilane.8 The reducing agent can be avoided using a Ru-
complex catalyst which oxidizes the alkyne into a ketone and after the F–C reaction with the indole reduces
the indolenine intermediate formed.9 Ketones can be directly used for the preparation of 3-alkylindoles but
obviously a silane reducing agent must be present in the reaction mixture.10-11 Modern procedures for the
alkylation of indoles employ primary and secondary alcohols as reactants in metal redox catalyzed
processes,12-14 or secondary alcohols in metal-free redox chain reactions.15 Finally a successful method using
primary and secondary amines in a Ru-catalyzed process is available for the synthesis of 3-alkylindoles.16
A
common feature of all the above cited procedures using alkynes, alcohols, amines and carbonyl derivatives as
reactants is the formation of an alkylideneindolenine intermediate 1 which by final regioselective reduction
leads to the target 3-alkylindole compound 2 (Scheme 1).
Scheme 1. General strategy for the synthesis of 3-alkylindoles.
Alkylideneindolenines of type 1 act as vinylogous imino derivatives and are known intermediates in several
processes leading to the synthesis of 3-functionalized indole derivatives via conjugate addition of various
nucleophilic species. Because of the limited stability of intermediates 1, these reactive electrophilic species are
usually generated in situ from bench stable precursors following the strategy depicted in Scheme 2.17
Scheme 2. Functionalization of indoles from alkylideneindolenine intermediates 4.
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A suitable leaving group (Lg) located at ‘benzylic position’ of derivatives 3 can be eliminated under basic
conditions leading to alkylideneindolenine 4 which upon nucleophilic addition leads to functionalized indole 5.
Among different precursors available for this purpose, 3-(1-arylsulfonylalkyl) indoles 6 (sulfonyl indoles) are
those which present better features since are mostly solid compounds stable enough to be easily purified and
stored.18 Sulfonyl indoles 6 can be readily obtained by a three component coupling of an indole, an aldehyde
and p-toluenesulfinic acid under acidic conditions (Scheme 3).19
Scheme 3. Synthesis of 3-(1-arylsulfonylalkyl) indoles (sulfonyl indoles) 6.
The arylsulfonyl group in sulfonyl indoles can be eliminated under very mild basic conditions allowing these
substrates to be successfully used even in asymmetric synthesis. It should be observed that several
nucleophilic reactants currently used in this process are basic enough to warrant the elimination of the
arylsulfonyl group of sulfonyl indoles 6 avoiding the need of an external base. Particularly, the utilization of
hydride donors would allow the direct conversion of sulfonyl indoles into 3-alkylindole derivatives. The
effectiveness of lithium aluminiumhydride for this purpose has been evidenced in the early studies focused on
the reactivity of sulfonyl indoles but this reagent often lacks of the required selectivity towards other
reductable functional groups.20 On the other hand, the use of some common reagents usually employed to
carry out desulfonylation processes such as tributyltin hydride or Na/Hg amalgam is no longer advisable for
sustainability reasons.21 Sodium borohydride has been successfully employed for the reduction of
functionalized sulfonyl indoles aimed at the preparation of tryptophol derivatives,22 and unsymmetrical
bisindoles.23 In these processes the utilization of sodium borohydride entails tedious work up operations,
involving solvent consumption and waste production which limit the sustainability of the procedure and often
leads to a yield erosion of the obtained products.
In this paper we present a new improved procedure for the preparation of 3-alkylindoles by reduction of
sulfonyl indoles under flow chemical conditions using polymer-supported borohydride (PS-BH4) as single
reactant. The combination of flow chemistry with the use of a solid supported species reduces the work-up
step just to a solvent evaporation, thus decreasing the time process and maximizing the productivity.24-26
Furthermore, a new one-pot synthesis of 3-alkylindoles starting from their remote precursors (indoles and
aldehydes) has been implemented thanks to the peculiarities of these technologies.
Results and Discussion
The experimental set up for studying this transformation involves (i) the use of two syringe pumps respectively
containing a solution of the appropriate sulfonyl indoles 6 (reservoir A) and the solvent used for pushing the
reaction into the line (reservoir B), (ii) a three-ways valve (V) used for connecting and selecting the reservoirs
to a (iii) packed bed reactor (R) containing the solid supported borohydride, and (iv) a back pressure regulator
set at 2 atm for maintaining constant the upstream pressure and flow rate. By means of this flow equipment,
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we preliminarily studied, for the conversion of 6a into 7a, the effect of different reaction parameters such as
stoichiometry and concentration of reactants, residence time and solvent (Scheme 4).
Scheme 4. General apparatus for the reduction of sulfonyl indole 6a to 3-hexylindole 7a.
Firstly, we screened a variety of solvents using 3 equivalents of supported borohydride and a residence time of
45 minutes. Under these conditions the best result was obtained using ethanol (Table 1, entry 7).
Table 1. Optimization studies with various solvents.
Entrya
1
Solvent (0.03M)
Toluene
Yield (%)b of 7a
Entrya
6
Solvent (0.03M)
MeCN
Yield (%)b of 7a
9%
-
2
3
4
5
EtOAc
-
-
-
7
8
9
10
EtOH
MeOH
i-PrOH
-valerolacton
61%
54%
53%
-
Dioxane
2-MeTHF
CH2Cl2
5%
a The reaction was performed using 3 equivalents of PS-BH4. b Yield of isolated pure product.
Then, we investigated different ethanolic solutions for the reduction of substrate 6a observing just a negligible
dependence of the chemical yield on the concentration of the substrate (Table 2). Anyway, since the use of a
0.05M solution appears to provide the best result, this concentration has been selected for the next
investigations. More concentrated solutions are poorly applicable because of the reduced solubility of our
substrates in ethanol (Table 2, Entry 5).
Table 2. Optimization studies testing different ethanolic concentrations of substrate 6a.
Entry
Ethanol (Conc. M)
Yield (%)a of 7a
1
2
3
4
5
0.03
0.04
0.02
0.05
0.06
61
60
59
63
c
-
a Conditions: 3 equivalents of PS-BH4, residence time of 45 min. b Yield of isolated pure product. c Low solubility.
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Finally, we tested various ratios of reducing agent at different flow rates, obtaining the best yield of 7a (85%)
using 6 equivalents of PS-BH4 with a residence time of 20 minutes (Table 3, entry 6).
Table 3. Optimization studies testing different amount of PS-BH4.
Entry
PS-BH4 (equiv.)
Residence timea
Yield (%)b of 7a
1
2
3
4
5
6
7
3
4.5
6
7.5
6
6
45 min
45 min
45 min
45 min
30 min
20 min
10 min
63
75
83
81
84
85
57
6
a Substrate concentration 0.05 M. b Yield of isolated pure product
In order to demonstrate the generality of our method we submitted a series of sulfonyl indoles 6 to the
optimized reaction conditions obtaining in all cases good yields even in the presence of sensible functional
groups (Scheme 5). The limited solubility of substrates 6d-g in ethanol required the utilization of 2-MeTHF as a
co-solvent for a proper reaction. A solvent ratio EtOH/2-MeTHF 8:2 ensures a viable process although the
residence time must be doubled up compared with the ethanol usage.
Scheme 5. Reduction of various sulfonyl indoles 6.
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Finally, the total flow synthesis of three representative compounds 7h-j was undertaken starting from indoles
and aldehydes for the generation of 3-alkylindoles in an integrated synthetic operation (Scheme 6). To this
aim, we adapted our original batch synthesis of sulfonyl indoles 6 to flow conditions in series with the
subsequent reduction step.12 As depicted in Scheme 6, the flow apparatus was made up of four different
reservoirs respectively containing the appropriate indole and aldehyde (reservoir A), a solution of pTolSO3H
and pTolSO2H (reservoir B), ethyl acetate used for pushing the reaction into the line (reservoir C), and ethanol,
necessary for the reduction step (reservoir D). Additionally, the apparatus was integrated with a coil reactor
(R1), in which the synthesis of 6 occurs, linked with a further packed bed reactor containing Amberlyst A21
(R2), used as scavenger for the acidic species, a four-ways valve (V1) used for connecting and selecting the
reservoirs to the coil reactor, and a T-connector (T) for joining the outgoing flow from R2 with the reservoir D
and the reactor R. The overall yield recorded for the obtained 3-alkylindoles 7h-j is quite satisfactory
considering the two synthetic operations carried out in this approach.
Scheme 6. Synthesis of 3-alkylindoles 7h-j from their indole and aldehyde remote precursors.
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Conclusions
The intrinsic difficulty in performing the direct C-3 alkylation of indole systems prompted us to develop a
synthetic procedure for the preparation of 3-alkylindoles by reduction of 3-(1-arylsulfonylalkyl) indoles
(sulfonyl indoles). In order to increase the sustainability of the process restraining the solvent consumption
and work up operations, the flow chemical conditions have been found as the more appropriate for the
reduction of sulfonyl indoles using polymer-supported sodium borohydride. Under optimized reaction
conditions, various 3-alkylindoles have been obtained in good yield just after solvent evaporation and column
chromatographic separation when required. Since sulfonyl indoles can be obtained by a three component
coupling of aldehydes, indoles and arylsulfinic acids, 3-alkylindoles have been also prepared directly starting
from these remote precursors embodying sulfonyl indole formation and then reduction in the same flow
device. The latter inclusive approach allows the preparation of a set of 3-alylindoles from the corresponding
indoles and aldehydes in satisfactory yields with notable waste minimization and reduced solvent
consumption.
Experimental Section
1
General. H-NMR analyses were recorded at 400 MHz on a Varian Mercury Plus 400. 13C-NMR analyses were
recorded at 100 MHz. IR spectra were recorded with a Perkin Elmer FT-IR spectrometer Spectrum Two UATR.
Microanalyses were performed with a CHNS-O analyzer Model EA 1108 from Fisons Instruments. GS-MS
analyses were obtained by a Hewlett-Packard GC/MS 6890N that works with the EI technique (70 eV).
Solutions in the flow apparatus were injected using syringe pumps model NE‐300 (New Era Pump Systems
Inc.). All chemical used are commercially available and were used without further purification. Sulfonyl indoles
6 were prepared according to literature method.19
General procedure for the flow reduction of 6 into 7. The flow equipment was set up according to the
Scheme 5. The appropriate sulfonyl indole 6a-c (0.25 mmol) was taken up in ethanol (5 mL) and the
corresponding solution was introduced into reservoir A, while the reservoir B was filled only with ethanol (10
mL). The solution of the reservoir A (4 mL) was pumped, with a flow rate of 0.05 mL/min, into the three-way
valve V and then through the packed bed reactor R containing PS-BH4 resin (1.2 mmol, 0.53 g, residence time
~20 min) and pressurized by a BPR set at 2 atm. When the allotted volume from reservoir A was delivered, the
valve V was switched from reservoir A to B, and a stream of ethanol (4 mL, 0.05 mL/min) was flowed through
the system to push out the residual sulfonyl indole. The outflow was collected in a 25 mL round bottom flask,
the solution was concentrated at reduced pressure and the crude product 7a-c was purified by flash column
chromatography on silica gel (hexanes/EtOAc 9:1).
For substrates 6d-g the same procedure was adopted except the solvent used (EtOH/2-MeTHF 8:2) and flow
rate of 0.025 mL/min, residence time of 40 min.
3-Hexyl-1H-indole (7a).27 Yellow oil. IR (neat): 3413, 2924, 2857, 1455, 738 cm-1. 1H-NMR (400 MHz, CDCl3): δ
0.96 (t, 3H, J 7.3 Hz), 1.27-1.57 (m, 6H), 1.70-1.85 (m, 2H), 2.81 (t, 2H, J 7.7 Hz), 6.97 (s, 1H), 7.18 (t, 1H, J 7.7
Hz), 7.25 (t, 1H, J 7.7 Hz), 7.37 (d, 1H, J 7.7 Hz), 7.68 (d, 1H, J 7.7 Hz), 7.81 (br s, 1H). 13C-NMR (100 MHz,
CDCl3): δ = 14.5, 23.0, 25.5, 29.7, 30.5, 32.1, 111.3, 117.4, 119.3, 121.3, 122.1, 127.9, 136.6. MS (EI): m/z (%) =
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201 (44, [M+]), 130 (100), 103 (9), 77 (10). Anal. Calcd for C14H19N (201.31): C, 83.53; H, 9.51; N, 6.96. Found: C,
83.57; H, 9.48; N, 6.99.
1
3-(Hex-5-enyl)-1H-indole (7b). Yellow oil. IR (neat): 3415, 2925, 1455, 909, 740 cm-1. H-NMR (400 MHz,
CDCl3): δ = 1.46-1.56 (m, 2H), 1.69-1.79 (m, 2H), 2.12 (q, 2H, J 6.75, 8.14 Hz), 2.77 (t, 1H, J 7.54), 4.93-5.05 (m,
2H), 5.78-5.89 (m, 1H), 6.98 (s, 1H), 7.10-7.15 (m, 1H), 7.17-7.22 (m, 1H), 7.36 (d, 1H, J 8.11 Hz), 7.62 (d, 1H, J
8.33 Hz), 7.89 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ = 25.2, 29.1, 29.9, 33.9, 111.3, 114.6, 117.2, 119.2,
119.3, 121.3, 122.1, 127.8, 136.6, 139.3. MS (EI): m/z (%) = 199 (19, [M+]), 156 (14), 130 (100), 103 (6), 77 (7).
Anal. Calcd for C14H17N (199.30): C, 84.37; H, 8.60; N, 7.03. Found: C, 84.41; H, 8.57; N, 7.05.
3-(4-tert-Butylbenzyl)-1H-indole (7c).28 Pale yellow solid, mp 124-126°C. IR (neat): 3404, 2960, 1455, 818, 742
cm-1. 1H-NMR (400 MHz, CDCl3): δ = 1.34 (s, 9H), 4.13 (s, 2H), 6.91-6.95 (m, 1H), 7.13 (t, 1H, J 7.7 Hz), 7.19-7.28
(m, 3H), 7.32-7.39 (m, 3H), 7.60 (d, 1H, J 8.1 Hz), 7.89 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ = 31.2, 31.7,
34.6, 111.2, 116.2, 119.5, 119.6, 122.3, 122.6, 125.5, 127.8, 128.6, 136.7, 138.4, 148.9. MS (EI): m/z (%) = 263
(100, [M+]), 244 (61), 232 (10), 206 (23), 130 (46), 110 (9). Anal. Calcd for C19H21N (263.38): C, 86.64; H, 8.04;
N, 5.32. Found: C, 86.68; H, 8.01; N, 5.35.
1
2-Methyl-3-propyl-1H-indole (7d).29 Pinkish oil. IR (neat): 3404, 2956, 2929, 1459, 1298, 738 cm-1. HNMR
(400 MHz, CDCl3): δ = 0.95 (t, 3H, J 7.3Hz), 1.60-1.72 (m, 2H), 2.37 (s, 3H), 2.68 (t, 2H, J 7.3 Hz), 7.04-7.14 (m,
2H), 7.25-7.28 (m, 1H), 7.52 (d, 1H, J 7.3 Hz), 7.68 (br s, 1H). 13CNMR (100 MHz, CDCl3): δ = 11.9, 14.3, 24.1,
26.4, 110.3, 112.5, 118.4, 119.2, 121.0, 129.1, 131.0, 135.5. MS (EI): m/z (%) = 173 (48, [M+]), 144 (100), 115
(10), 77 (9). Anal. Calcd for C12H15N (173.26): C, 83.19; H, 8.73; N, 8.08. Found: C, 83.23; H, 8.70; N, 8.11.
2-Methyl-3-(3-phenylpropyl)-1H-indole (7e).20 Pale yellow solid, mp 76-79°C. IR (neat): 3413, 3054, 2920,
2848, 1459, 1298, 738, 702 cm-1. 1H-NMR (400 MHz, CDCl3): δ 1.97-2.08 (m, 2H), 2.36 (s, 3H), 2.73 (t, 2H, J 7.7
Hz), 2.79 (t, 2H, J 7.7 Hz), 7.09-7.36 (m, 8H), 7.53 (d, 1H, J 7.3 Hz), 7.64 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ
= 12.0, 24.1, 32.5, 36.0, 110.4, 112.1, 118.4, 119.3, 121.1, 125.9, 128.5, 128.7, 129.0, 131.1, 135.5, 142.9. MS
(EI): m/z (%) = 249 (72, [M+]), 144 (100), 130 (14), 115 (10), 91 (10), 77 (10). Anal. Calcd for C18H19N (249.36): C,
86.70; H, 7.68; N, 5.62. Found: C, 86.74; H, 7.71; N, 5.59.
3-(4-Bromobenzyl)-2-methyl-1H-indole (7f).30 Pale yellow solid, mp 122-125°C. IR (neat): 3440, 2902, 1486,
1
1459, 1437, 1011, 747 cm-1. H-NMR (400 MHz, CDCl3): δ 2.38 (s, 3H), 4.02 (s, 2H), 7.01-7.16 (m, 4H), 7.29 (d,
1H, J 8.1 Hz), 7.34-7.39 (m, 3H), 7.80 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ = 12.0, 29.8, 110.1, 110.5, 118.4,
119.6, 121.4, 128.9, 130.2, 131.5, 132.0, 135.5, 140.9. MS (EI): m/z (%) = 299 (49), 284 (20), 204 (12), 144
(100), 109 (14), 102 (17). Anal. Calcd for C16H14BrN (300.2): C, 64.02; H, 4.70; N, 4.67. Found: C, 64.06; H, 4.73;
N, 4.70.
2-((1H-Indol-3-yl)methyl)benzonitrile (7g). Pale yellow viscous oil. IR (neat): 3411, 3063, 2225, 1455, 732 cm-1.
1H-NMR (400 MHz, CDCl3): δ 4.35 (s, 2H), 7.06-7.15 (m, 2H), 7.22 (t, 1H, J 8.2), 7.27 (t, 1H, J 6.8), 7.34-7.39 (m,
2H), 7.55 (d, 1H, J 8.0 Hz), 7.65 (d, 1H, J 7.64 Hz), 8.10 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ 30.5, 111.6,
112.5, 113.4, 118.6, 119.1, 119.9, 122.5, 123.3, 126.8, 127.3, 130.0, 133.1, 136.6, 145.4. MS (EI): m/z (%) = 232
(100), 204 (10), 130 (75), 102 (10). Anal. Calcd for C16H12N2 (232.29): C, 82.73; H, 5.21; N, 12.06. Found: C,
82.77; H, 5.24; N, 12.04.
General one-pot procedure for the synthesis of 3-alkylindoles 7h-j.
The flow equipment was set up according to the Scheme 6. The appropriate indole (0.3 mmol) and aldehyde
(0.3 mmol) were taken up in EtOAc (3 mL) and then introduced into reservoir A. Reservoir B was filled with a
solution of pTolSO3HH2O (0.15 mmol, 28 mg) and pTolSO2H (0.36 mmol, 56 mg) in EtOAc (3 mL), while the
reservoir C was filled only with the EtOAc. The two solutions (2 mL each) were simultaneously pumped with a
flow rate of 0.005 mL/min for each pump into the V1 four-way valve before passing through a 1.8 mL coil
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reactor (residence time 3 h) and the packed bed reactor R2 containing 0.5 g of Amberlyst A21. The outflow
stream was subsequently connected by a T-piece mixer (T) with the reservoir D (ethanol, flow rate 0.04
mL/min) and pushed through the packed bed reactor R containing PS-BH4 resin (1.2 mmol, 0.53 g, residence
time 20 min). The system was pressurized by a BPR set at 2 atm. Finally, fresh ethyl acetate (reservoir C) was
used, by switching the valve V1 to flow the residual solution through the system. The outflow was collected in
a 100 mL round bottom flask, the solution was concentrated at reduced pressure and the crude product 7 was
purified by flash column chromatography.
3-(4-tert-Butylbenzyl)-2-methyl-1H-indole (7h). Pale yellow solid, mp 136-138°C. IR (neat): 3395, 2956, 1463,
830, 744 cm-1. 1H-NMR (400 MHz, CDCl3): δ = 1.30 (s, 9H), 2.40 (s, 3H), 4.05 (s, 2H), 7.05 (dt, 1H, J 0.8, 7.3 Hz),
7.12 (dt, 1H, J 0.8, 7.3 Hz), 7.17 (d, 2H, J 8.1 Hz), 7.25-7.30 (m, 3H), 7.44 (d, 1H, J 7.7 Hz), 7.75 (br s, 1H). 13C-
NMR (100 MHz, CDCl3): δ = 12.1, 29.8, 31.7, 34.5, 110.4, 111.0, 118.7, 119.4, 121.2, 125.4, 128.1, 129.2, 131.8,
135.5, 138.8, 148.6. MS (EI): m/z (%) = 277 (100, [M+]), 262 (57), 220 (14), 144 (71). Anal. Calcd for C20H23N
(277.41): C, 86.59; H, 8.36; N, 5.05. Found: C, 86.63; H, 8.39; N, 5.08.
7-Ethyl-3-hexyl-1H-indole (7i). Pale yellow oil. IR (neat): 3419, 2929, 1432, 1076, 744 cm-1. 1H-NMR (400 MHz,
CDCl3): δ 0.90 (t, 3H, J 7.3 Hz), 1.28-1.46 (m, 9H), 1.66-1.77 (m, 2H), 2.75 (t, 2H, J 7.7 Hz), 2.86 (q, 2H, J 7.7 Hz),
6.98 (s, 1H), 7.01-7.12 (m, 2H), 7.48 (d, 1H, J 7.7 Hz), 7.86 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ 14.1, 14.4,
23.0, 24.3, 25.5, 29.6, 30.4, 32.0, 117.0, 117.9, 119.6, 120.6, 120.8, 126.6, 127.6, 131.4. MS (EI): m/z (%) = 229
(28, [M+]), 158 (100), 143 (10). Anal. Calcd for C16H23N (229.37): C, 83.79; H, 10.11; N, 6.11. Found: C, 83.76; H,
10.08; N, 6.08.
3-(4-Nitrobenzyl)-2-phenyl-1H-indole (7j). Yellow viscous oil. IR (neat): 3407, 3059, 1708, 1597, 1514, 1459,
1340, 732 cm-1. 1H-NMR (400 MHz, CDCl3): δ 4.36 (s, 2H), 7.10 (dt, 1H, J 0.9, 8.1 Hz), 7.24 (dt, 1H, J 0.9, 8.1 Hz),
7.33-7.50 (m, 9H), 8.10 (d, 2H, J 8.5 Hz), 8.24 (br s, 1H). 13C-NMR (100 MHz, CDCl3): δ = 149.7, 136.2, 132.7,
129.3, 129.2, 128.4, 128.1, 124.0, 123.0, 120.4, 119.3, 111.3, 109.6, 30.8. MS (EI): m/z (%) = 328 (100, [M+]),
281 (10), 206 (83), 178 (8). Anal. Calcd for C21H16N2O2 (328.37): C, 76.81; H, 4.91; N, 8.53. Found: C, 76.85; H,
4.94; N, 8.56.
Acknowledgements
The authors thank the University of Camerino for the financial support.
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