New hypoxia-selective cytotoxines derived from quinoxaline 1,4-dioxides

DOI: 10.1002/jhet.5570320420

Source and publish data:

Journal of Heterocyclic Chemistry p. 1213 - 1217 (1995)

Update date:2022-08-04

Topics:

Authors:

Monge Monge

Palop Palop

Gonzalez

Martinez-Crespo

Lopez De Cerain

Sainz Sainz

Narro Narro

Barker Barker

Hamilton

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Article abstract of DOI:10.1002/jhet.5570320420

A new series of quinoxaline 1,4-dioxides, structurally related to the benzotriazine tirapazamine 1 have been prepared starting from 5,6-dichlorobenzofuroxane 2. The Beirut reaction between 2 and alkyl or aryl thiopropanones afforded the 2-methyl-3-alkyl(a

Full text of DOI:10.1002/jhet.5570320420

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