Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues

DOI: 10.1016/S0960-894X(99)00286-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1761 - 1766 (1999)

Update date:2022-08-03

Topics:

Authors:

Yang, Lihu

Morriello, Greg

Leung, Kwan

Jacks, Tom

Cheng, Kang

Schleim, Klaus D.

Smith, Roy

Patchett, Arthur A.

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Article abstract of DOI:10.1016/S0960-894X(99)00286-3

Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.

Full text of DOI:10.1016/S0960-894X(99)00286-3

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