Total synthesis of brevetoxin B. 1. First generation strategies and new approaches to oxepane systems

Article abstract of DOI:10.1021/ja00146a008

The first generation strategies toward the total synthesis of brevetoxin B (1) are presented and the syntheses of the key intermediates 3, 4, 5, 67, 83, and 94-98 required for the projected construction are described. The earliest and most convergent stra