Tetrahedron Letters p. 9433 - 9436 (1995)
Update date:2022-08-05
Topics:
Miller, William H.
Ku, Thomas W.
Ali, Fadia E.
Bondinell, William E.
Calvo, Raul R.
Davis, Larry D.
Erhard, Karl F.
Hall, Leon B.
Huffman, William F.
Keenan, Richard M.
Kwon, Chet
Newlander, Kenneth A.
Ross, Stephen T.
Samanen, James M.
Takata, Dennis T.
Yuan, Chuan-Kui
An enantiospecific synthesis of SB 214857, a potent, nonpeptide fibrinogen receptor antagonist, is reported. The synthetic route employs as a key step an intramolecular aryl fluoride displacement to form the seven-membered ring of the 1,4-benzodiazepine s
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