Configuration d'esters derives d'acides 2-fluoro-2-phenylacetique phenyles substitues, par RMN du fluor

Article abstract of DOI:10.1016/S0022-1139(00)80114-1

The 19 F NMR chemical shifts (δ_F) of the p-ZPhCHFCO2CHL¹L² esters of 2-fluoro-2-substituted aryl acetic acids have been measured.The δ_F values of the two diastereoisomers of these esters are linearly related to the ?⁺ Brown-Okamoto substituent parameters for each term of the series studied.The configuration of such esters of arylacetic acid can be deduced from their δ_F values when compared to those of esters derived from the non-substituted acid of known configuration.