A Novel Synthesis of 19-Nor 1α,25-dihydroxyvitamin D3 and Related Analogues

DOI: 10.1016/0040-4039(95)01730-6

Source and publish data:

Tetrahedron Letters p. 8299 - 8302 (1995)

Update date:2022-08-03

Topics:

Authors:

Huang, Pei-qiang

Sabbe, Katrien

Pottie, Mieke

Vandewalle, Maurits

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Article abstract of DOI:10.1016/0040-4039(95)01730-6

19-Nor-1α,25-dihydroxyvitamin D3 (2) was synthesized from A-ring precursor 5 and ketone 4.Two synthesis of 5 were studied; one starting from (-)-quinic acid as a template and one starting from cis-1,3,5-cyclohexanetriol via a chemoenzymatic approach.

Full text of DOI:10.1016/0040-4039(95)01730-6

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