A Chemoenzymatic Synthesis of Both Enantiomers of 2-Phenyl-3-hydroxypropylcarbamate, a Metabolite of Felbamate

Article abstract of DOI:10.1016/0957-4166(95)00222-B

PPL catalyzed desymmetrization of 2-phenyl-1,3-propanediol (3) was the key step in the chemoenzymatic synthesis of both enantiomers of 2-phenyl-3-hydroxypropylcarbamate (2).Unsuccessful attempts at enzyme catalyzed (PPL, Novo SP435) transcarbamoylation, aminolysis and ammonolysis are also described.