Diastereoselective Reduction and Organometal Addition to 1-Alkoxy-2-phenylalkan-3-ones

DOI: 10.1016/0040-4020(95)00602-5

Source and publish data:

Tetrahedron p. 10343 - 10360 (1995)

Update date:2022-08-05

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Authors:

Guanti, Giuseppe

Banfi, Luca

Riva, Renata

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Article abstract of DOI:10.1016/0040-4020(95)00602-5

The reduction with various hydrides and the addition of some Grignard reagents and aklyl lithiums to various protected 1-hydroxy-2-phenylalkan-3-ones furnished respectively the corresponding secondary and tertiary alcohols with a diastereoselectivity from good to excellent.Both processes were stereoconservative, no racemization being observed.

Full text of DOI:10.1016/0040-4020(95)00602-5

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