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Ozonolysis of (cyclohexa-1,4-dienyl)-L-alanine. An approach to the synthesis of new unnatural aminoacids. X-Ray molecular structure of 2-hydroxy-7-methyl-3-phenylpyrazolopyrimidine

DOI: 10.1039/P19950002509

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2509 - 2516 (1995)

Update date:2022-08-05

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Authors:

Zvilichovsky, GuryZvilichovsky, Gury

Gurvich, VadimGurvich, Vadim

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Article abstract of DOI:10.1039/P19950002509

The aromatic ring in L-phenylalanine was transformed into isoxazolyl, N-phenylpyrazolyl, and the bicyclic pyrazolo<1,5-a>pyrimidinyl groups, by a combination of Birch reduction and ozonolysis, followed by condensation with the relevant binucleophiles.The ozonolysis was carried out on the N-acylated esters of cyclohexa-1,4-dienylalanine.The resulting N-acylated esters of heterocyclic alanine derivatives were obtained without isolation of the ozonolysis products. 4-Phenylpyrazolidine-3,5-dione was used as a 'hydrazine donor' in the construction of pyrazolyl group, as direct condensation with hydrazine was successful.

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Product name:N-benzoyl(cyclohexa-1,4-dienyl)-L-alanine

Cas No:171898-35-4

171898-35-4

R&D Labs maybe for 171898-35-4

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