Enantiomerically Pure 3-Oxa-2,7-diazabicyclooctanes: Preparation, Analysis of Conformation and Test for Enantioselective Catalysis

Article abstract of DOI:10.1016/0040-4020(95)00630-Q

Amino alcohols 5 were prepared by various methods starting from (S)-(+)-alanine and (S)-(+)-valine.Swern oxidation of 5 afforded aldehydes 6 which were treated without isolation with N-alkylhydroxylamines to give nitrones 7A, B.These underwent spontaneous