Total synthesis of modified JSTX toxins: Reductive alkylation is a practical route to hexahydropyrimidine polyamine amides

DOI: 10.1016/0040-4039(95)01995-T

Source and publish data:

Tetrahedron Letters p. 9397 - 9400 (1995)

Update date:2022-08-03

Topics:

Authors:

Ashton, Mark R.

Moya, Eduardo

Blagbroug, Ian S.

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Article abstract of DOI:10.1016/0040-4039(95)01995-T

Reductive alkylation is a practical route for a total synthesis of regioisomers of spider toxin JSTX-3, a polyamine amide which is a selective glutamate receptor antagonist and may have potential as a neuroprotective agent. The strategy is based upon a re

Full text of DOI:10.1016/0040-4039(95)01995-T

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