Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase

DOI: 10.1016/0968-0896(96)00072-7

Source and publish data:

Bioorganic and Medicinal Chemistry p. 825 - 836 (1996)

Update date:2022-08-03

Topics:

Authors:

Wu, Ronghui

Saab, Nada H.

Huang, Huatao

Wiest, Laurie

Pegg, Anthony E.

Casero Jr., Robert A.

Woster, Patrick M.

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Article abstract of DOI:10.1016/0968-0896(96)00072-7

Polyamine analogues such as bis(ethyl)norspermine and N¹-ethyl-N¹¹-[(cyclopropyl)methyl]-4,8-diazaundecane (CPENSpm) act as inhibitors of the enzyme spermidine/spermine-N¹-acetyltransferase (SSAT) in vitro and possess impr

Full text of DOI:10.1016/0968-0896(96)00072-7

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