Design and evaluation of nonpeptide fibrinogen γ-chain based GPIIb/IIIa antagonists

DOI: 10.1021/jm00010a002

Source and publish data:

Journal of Medicinal Chemistry p. 1582 - 1592 (1995)

Update date:2022-09-26

Topics:

Authors:

Hoekstra

Beavers Beavers

Andrade-Gordon

Evangelisto

Keane Keane

Press Press

Tomko Tomko

Fan Fan

Kloczewiak

Mayo Mayo

Durkin Durkin

Liotta Liotta

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Article abstract of DOI:10.1021/jm00010a002

Two series of nonpeptide turn mimetics were designed by analysis of the solution NMR structure of the 385-411 sequence of the γ-chain of fibrinogen. These compounds, based on the KQAGD (Lys-Gln-Ala-Gly-Asp, 406-410) sequence, were synthesized and studied

Full text of DOI:10.1021/jm00010a002

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