Journal of Pharmaceutical Sciences p. 119 - 120 (1977)
Update date:2022-08-03
Topics: Synthesis Pharmacological evaluation Chemical Structure Experimental Design
Borne
Bedford
Buelke
Craig
Hardin
Kibbe
Wilson
An improved synthesis of norcocaine, a metabolite of cocaine, is reported. Following intravenous administration to a rhesus monkey, respiratory effects were similar to those observed following cocaine treatment. In addition, clonic convulsions, hypothermia, and mydriasis resulted. Norcocaine could be responsible for part of the pharmacological activity of cocaine.
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(1980)
