Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

DOI: 10.1016/0040-4020(95)00896-G

Source and publish data:

Tetrahedron p. 305 - 318 (1996)

Update date:2022-07-29

Topics: Experimental terms Retroamide Proteolytic enzymes

Authors:

Schirlin

Baltzer Baltzer

Altenburger

Tarnus Tarnus

Remy Remy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(95)00896-G

The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright

Full text of DOI:10.1016/0040-4020(95)00896-G

Products guided by the article

Product name:(R,S)-N-(4-nitrobenzyloxycarbonyl)-O-benzyl-tyrosinal

Cas No:173918-49-5

R&D Labs maybe for 173918-49-5

Zibo Xiaoguang Chemical Material Co., Ltd

Contact:15954099116

Address:Boshan Development Zone
Hunan Dinuo Pharmaceutical Co.,Ltd.

Contact:86-731-88280100*8561

Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Changzhou Sunlight Pharmaceutical Co., Ltd.

Contact:+86-519-83131668;83139028;83138042;83137041

Address:JiuliStreet, Benniu Town Changzhou City, Jiangsu Province
Hangzhou Ledun Technology Co.,Ltd.

Contact:86-571-18767088918

Address:No.6 street,XiaSha,Hangzhou,China.
Anhui Xinyuan Technology Co.,Ltd

Contact:0086-559-3515800

Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China

Relevant to this article

Convenient synthesis of ethylene carbonates from carbon dioxide and 1,2-diols at atmospheric pressure of carbon dioxide

Doi:10.1080/00397911.2015.1116583
(2016)
Ring contraction of 1,4-benzodiazepines to 3,4-dihydroquinazolines during macro scale reduction (example 5: Cyprazepam)

Doi:10.1002/ardp.19923250810
(1992)
Total synthesis and structural elucidation of the antifungal agent papulacandin D

Doi:10.1021/jo951895e
(1996)
Gram-scale synthesis of α,α-trehalose 6-monophosphate and α,α- trehalose 6,6'-diphosphate

Doi:10.1016/0008-6215(94)84050-4
(1994)
Efficient and regioselective nickel-catalyzed [2 + 2 + 2] cyclotrimerization of ynoates and related alkynes

Doi:10.1039/c3ob41872c
(2013)
Epoxidation of styrenes by hydrogen peroxide as catalyzed by methylrhenium trioxide

Doi:10.1021/ja00141a016
(1995)

Article Doi