Difluoromethyleneketone retroamide, a versatile concept of inactivation of proteolytic enzymes

DOI: 10.1016/0040-4020(95)00896-G

Source and publish data:

Tetrahedron p. 305 - 318 (1996)

Update date:2022-07-29

Topics: Experimental terms Retroamide Proteolytic enzymes

Authors:

Schirlin

Baltzer Baltzer

Altenburger

Tarnus Tarnus

Remy Remy

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Article abstract of DOI:10.1016/0040-4020(95)00896-G

The synthesis of difluoromethyleneketone retroamides is described. Several examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept. Copyright

Full text of DOI:10.1016/0040-4020(95)00896-G

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