Journal of the Chemical Society. Perkin transactions I p. 307 - 309 (1981)
Update date:2022-09-26
Topics:
Santaniello, Enzo
Manzocchi, Ada
Biondi, Pier Antonio
By decarboxylation of (2S)-histidine (1) in 2H2O in the presence of histidine decarboxylase from Clostridium welchii, monodeuteriated histamine (2a) was obtained.Ruthenium tetraoxide oxidation of (2a) furnished deuteriated β-alanine (3a), which was converted into the methyl ester of its phthaloyl derivative (6c).This compound showed a negative optical rotation, as did (6a), prepared from (3R)-(3c).From these results an (R)-configuration can be attributed to (2a) and consequently decarboxylation of (1) proceeds with retention of configuration.
View MoreShanghai Sunway Pharmaceutical Technology Co.,Ltd.
Contact:+86-21-5161 3915
Address:Shanghai YangPu
Nantong Auxin Electronic Technology Co., LTD
Contact:86-513-88760026
Address:NO.5-1, Aoxin Road, Haian Hi-tech Development Zone, Jiangsu Province, China
Contact:+86-519-86339586，13584329896
Address:Changzhou Scientific and Education Park
PINGYUAN SIHUAN PHARMACEUTICAL CO., LTD
Contact:+86-531-55696072
Address:#2766,yinxiu Road, Economic Development Zone, Pingyuan Country, Shandong Province, China.
ShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
Doi:10.1016/j.bmc.2015.12.001
(2016)Doi:10.1016/0957-4166(96)00199-1
(1996)Doi:10.1007/s11426-021-1032-7
(2021)Doi:10.1039/a902938i
(1999)Doi:10.1016/j.tetlet.2009.12.075
(2010)Doi:10.1016/j.tetasy.2006.11.020
(2006)
