Bioorganic and Medicinal Chemistry Letters p. 1757 - 1762 (1997)
Update date:2022-08-05
Topics:
Cherney, Robert J.
Decicco, Carl P.
Nelson, David J.
Wang, Li
Meyer, Dayton T.
Hardman, Karl D.
Copeland, Robert A.
Arner, Elizabeth C.
Several carboxylate derivatives with variation at the P1' residue were synthesized and evaluated as stromelysin (MMP-3) inhibitors. Compounds containing a bipbenyl moiety at P1' were found to be potent inhibitors of MMP-3. An X-ray crystal structure of the most potent compound, carboxylate 19, revealed an important interaction between the inhibitor's biphenyl and histidine 224 in the S1' pocket of MMP-3.
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