Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

DOI: 10.1016/S0960-894X(98)00238-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1431 - 1436 (1998)

Update date:2022-07-29

Topics:

Authors:

Barakat, Khaled J.

Cheng, Kang

Chan, Wanda W.-S

Butler, Bridget S.

Jacks, Thomas M.

Schleim, Klaus D.

Hora Jr., Donald F.

Hickey, Gerard J.

Smith, Roy G.

Patchett, Arthur A.

Nargund, Ravi P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00238-8

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC₅₀ = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.

Full text of DOI:10.1016/S0960-894X(98)00238-8

Products guided by the article

Product name:(1-Methyl-1-{(R)-1-[4-(2-nitro-phenyl)-piperazine-1-carbonyl]-4-phenyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Cas No:174855-55-1

R&D Labs maybe for 174855-55-1

Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
Xinchang Jiu Xin Pharmaceutical Co., Ltd

website:http://www.jiuxinpharm.com

Contact:86 137 5756 8585

Address:Poyang industry Park
NanJing KaiHeng Chemical CO., LTD.

Contact:+86-25-85768391

Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
Disynthesis Chemical Technology Co. Ltd.

Contact:+86-571-88194596

Address:Dengyun road 380, Gongshu district, Hangzhou city, China
Angelisun(Chongqing) Pharmaceutical Co., LTD.

Contact:+86-23-68030926-816

Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China

Relevant to this article

Intramolecular reactivity of functionalized arylcarbenes: 2-Allyloxyphenylcarbenes

Doi:10.1016/S0040-4039(97)00090-7
(1997)
Mimics of L-rhamnose: Analogues of rhamnopyranose containing a constituent α-amino acid at the anomeric position. A rhamnopyranose analogue of hydantocidin

Doi:10.1016/0957-4166(96)00014-6
(1996)
Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine

Doi:10.1016/S0040-4020(97)00520-6
(1997)
Synthesis of a heteroditopic cryptand capable of imposing a distorted coordination geometry onto Cu(II): Crystal structures of the cryptand (L), [Cu(L)(CN)](picrate), and [Cu(L)(NCS)](picrate) and spectroscopic studies of the Cu(II) complexes

Doi:10.1021/ic950933+
(1996)
Stereoselective synthesis of the isosteric phosphono analogues of N-acetyl-α-D-glucosamine 1-phosphate and N-acetyl-α-D-mannosamine 1-phosphate

Doi:10.1021/jo9519468
(1996)
Diastereoselective synthesis of (1S,2S,3R,6S) 3-chloro-3-methyl-6-isopropenyl-1,2-cyclohexanediol via Prins reaction induced by zinc and trimethylsilyl chloride

Doi:10.1016/0040-4020(96)00167-6
(1996)

Article Doi