Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

Article abstract of DOI:10.1016/S0960-894X(98)00238-8

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC₅₀ = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.