Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

DOI: 10.1016/S0960-894X(98)00238-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1431 - 1436 (1998)

Update date:2022-07-29

Topics:

Authors:

Barakat, Khaled J.

Cheng, Kang

Chan, Wanda W.-S

Butler, Bridget S.

Jacks, Thomas M.

Schleim, Klaus D.

Hora Jr., Donald F.

Hickey, Gerard J.

Smith, Roy G.

Patchett, Arthur A.

Nargund, Ravi P.

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Article abstract of DOI:10.1016/S0960-894X(98)00238-8

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC₅₀ = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.

Full text of DOI:10.1016/S0960-894X(98)00238-8

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