Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

DOI: 10.1016/S0960-894X(98)00238-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1431 - 1436 (1998)

Update date:2022-07-29

Topics:

Authors:

Barakat, Khaled J.

Cheng, Kang

Chan, Wanda W.-S

Butler, Bridget S.

Jacks, Thomas M.

Schleim, Klaus D.

Hora Jr., Donald F.

Hickey, Gerard J.

Smith, Roy G.

Patchett, Arthur A.

Nargund, Ravi P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00238-8

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC₅₀ = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.

Full text of DOI:10.1016/S0960-894X(98)00238-8

Products guided by the article

Product name:(1-Methyl-1-{(R)-1-[4-(2-nitro-phenyl)-piperazine-1-carbonyl]-4-phenyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Cas No:174855-55-1

R&D Labs maybe for 174855-55-1

uni source industries limited

Contact:86 21 3772 9386

Address:Rm.1803,Starry Bldg.1,1505 Meijiabang Road,Shanghai 201620 China
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:

Address:Chungking Express Nos.36 Nathan Road，Kowloon, HK
CHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD

website:http://www.fengrunhuagong.com

Contact:+86-536-7869976

Address:Changyi Coastal Economic Development Zone
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd

Contact:+86-0517-87036900

Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china

Relevant to this article

Intramolecular reactivity of functionalized arylcarbenes: 2-Allyloxyphenylcarbenes

Doi:10.1016/S0040-4039(97)00090-7
(1997)
Mimics of L-rhamnose: Analogues of rhamnopyranose containing a constituent α-amino acid at the anomeric position. A rhamnopyranose analogue of hydantocidin

Doi:10.1016/0957-4166(96)00014-6
(1996)
Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine

Doi:10.1016/S0040-4020(97)00520-6
(1997)
Synthesis of a heteroditopic cryptand capable of imposing a distorted coordination geometry onto Cu(II): Crystal structures of the cryptand (L), [Cu(L)(CN)](picrate), and [Cu(L)(NCS)](picrate) and spectroscopic studies of the Cu(II) complexes

Doi:10.1021/ic950933+
(1996)
Stereoselective synthesis of the isosteric phosphono analogues of N-acetyl-α-D-glucosamine 1-phosphate and N-acetyl-α-D-mannosamine 1-phosphate

Doi:10.1021/jo9519468
(1996)
Diastereoselective synthesis of (1S,2S,3R,6S) 3-chloro-3-methyl-6-isopropenyl-1,2-cyclohexanediol via Prins reaction induced by zinc and trimethylsilyl chloride

Doi:10.1016/0040-4020(96)00167-6
(1996)

Article Doi