Synthesis and biological activities of phenyl piperazine- based peptidomimetic growth hormone secretagogues

DOI: 10.1016/S0960-894X(98)00238-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1431 - 1436 (1998)

Update date:2022-07-29

Topics:

Authors:

Barakat, Khaled J.

Cheng, Kang

Chan, Wanda W.-S

Butler, Bridget S.

Jacks, Thomas M.

Schleim, Klaus D.

Hora Jr., Donald F.

Hickey, Gerard J.

Smith, Roy G.

Patchett, Arthur A.

Nargund, Ravi P.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00238-8

A new class of potent, orally active phenyl piperazine-based GH secretagogues have been discovered from attempts to mimic the arrangement of the phenyl substitutent in the spiroindanyl piperidine and spiroindoline sulfonamide privileged structures of 4 and 1, respectively. The best of these compounds, 18 (EC₅₀ = 2.8 nM) is nearly as potent as MK-0677 for releasing GH from rat pituitary cells.

Full text of DOI:10.1016/S0960-894X(98)00238-8

Products guided by the article

Product name:(1-Methyl-1-{(R)-1-[4-(2-nitro-phenyl)-piperazine-1-carbonyl]-4-phenyl-butylcarbamoyl}-ethyl)-carbamic acid tert-butyl ester

Cas No:174855-55-1

R&D Labs maybe for 174855-55-1

Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)

Contact:18957018777 +86-570-3888777

Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Beijing Century Richap Chemistry Co.,Ltd

Contact:+86- 010-64455497

Address:Guannan County, Lianyungang City, Jiangsu Province, China
HEZE KINGVOLT CHEMICAL CO., LTD

Contact:86-573-82118911

Address:Juancheng Industry Park
Arshine Pharmaceutical Co., Limited

website:http://www.cnarshine.com

Contact:0731-88503671

Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China
Ningbo Tide Imp. & Exp. Co., Ltd.

Contact:+86-571-8993 7933; +86-571-8993 6453

Address:7/F Anno Domini Building, Tower South, 8 Qiu Shi Road,Hangzhou,China.

Relevant to this article

Intramolecular reactivity of functionalized arylcarbenes: 2-Allyloxyphenylcarbenes

Doi:10.1016/S0040-4039(97)00090-7
(1997)
Mimics of L-rhamnose: Analogues of rhamnopyranose containing a constituent α-amino acid at the anomeric position. A rhamnopyranose analogue of hydantocidin

Doi:10.1016/0957-4166(96)00014-6
(1996)
Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine

Doi:10.1016/S0040-4020(97)00520-6
(1997)
Synthesis of a heteroditopic cryptand capable of imposing a distorted coordination geometry onto Cu(II): Crystal structures of the cryptand (L), [Cu(L)(CN)](picrate), and [Cu(L)(NCS)](picrate) and spectroscopic studies of the Cu(II) complexes

Doi:10.1021/ic950933+
(1996)
Stereoselective synthesis of the isosteric phosphono analogues of N-acetyl-α-D-glucosamine 1-phosphate and N-acetyl-α-D-mannosamine 1-phosphate

Doi:10.1021/jo9519468
(1996)
Diastereoselective synthesis of (1S,2S,3R,6S) 3-chloro-3-methyl-6-isopropenyl-1,2-cyclohexanediol via Prins reaction induced by zinc and trimethylsilyl chloride

Doi:10.1016/0040-4020(96)00167-6
(1996)

Article Doi