Optically active antifungal axoles. V. Synthesis and antifungal activity of stereoisomers of 3-Azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols

DOI: 10.1248/cpb.43.441

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 441 - 449 (1995)

Update date:2022-08-04

Topics:

Authors:

Tasaka Tasaka

Tsuchimori

Kitazaki

Hiroe Hiroe

Hayashi Hayashi

Okonogi Okonogi

Itoh Itoh

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Article abstract of DOI:10.1248/cpb.43.441

The (2S,3S)-, (2R,3S)- and (2S,3R)-stereoisomers of (2R,3R)-3-azolyl-2-(substituted phenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanols [(2R,3R)-1a-d] were prepared and evaluated for antifungal activity against Candida albicans in vitro and in vivo to clarify th

Full text of DOI:10.1248/cpb.43.441

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