First synthesis of enantiomerically pure carbocyclic oxanosine as a potential chemotherapeutic agent

Article abstract of DOI:10.1016/0960-894X(96)00006-6

The first synthesis of optically active carbocyclic oxanosine 2 has been achieved in 14 steps from commercially available D-ribonic acid γ-lactone. When evaluated for the inhibition activity of NGF-induced differentiation on PC12 cells, 2 was about 10-fold less active than natural oxanosine. Copyright