Synthesis of 2-substituted 1,3-oxazin-6-ones by gas-phase pyrolysis

Article abstract of DOI:10.1016/0040-4020(95)01102-1

Acylaminomethylene Meldrum's acid derivatives 5 are prepared either by direct reaction of methoxymethylene Meldrum's acid 4 with primary amides, or by acylation of aminomethylene Meldrum's acid 6. Pyrolysis of the substrates 5 under FVP conditions gives the title compounds 8 in good yields.