Bioorganic and Medicinal Chemistry Letters p. 671 - 674 (1996)
Update date:2022-08-04
Topics:
Bedeschi, Angelo
Zarini, Franco
Cabri, Walter
Candiani, Ilaria
Penco, Sergio
Capolongo, Laura
Ciomei, Marina
Farao, Mariella
Grandi, Maria
A new family of water soluble camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.
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Doi:10.1246/bcsj.40.2904
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(1985)
