Synthesis and antitumor activity of a new class of water soluble camptothecin derivatives

DOI: 10.1016/0960-894X(96)00083-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 671 - 674 (1996)

Update date:2022-08-04

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Authors:

Bedeschi, Angelo

Zarini, Franco

Cabri, Walter

Candiani, Ilaria

Penco, Sergio

Capolongo, Laura

Ciomei, Marina

Farao, Mariella

Grandi, Maria

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Article abstract of DOI:10.1016/0960-894X(96)00083-2

A new family of water soluble camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and in vivo antitumor activity is reported. Compounds 5a and 5c displayed excellent in vivo antitumor activity both ip and iv.

Full text of DOI:10.1016/0960-894X(96)00083-2

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