Chemical and Pharmaceutical Bulletin p. 288 - 295 (1996)
Update date:2022-07-29
Topics:
Minakawa
Sasabuchi
Kiyosue
Kojima
Matsuda
An efficient and large scale chemical synthesis of 5-aminoimidazole-4- carboxamide (AICA) 2'-deoxyriboside (5a) and its 3'-deoxyriboside 5b is described. Treatment of 3',5'-di-O-acetyl-N1-triphenylmethyl-2'-deoxyinosine (3a) with 5N NaOH in EtOH, followed by anhydrous trifluoroacetic acid gave 5a in 59% yield from 2'-deoxyinosine (1a). AICA 3'-deoxyriboside (5b) was also obtained in a similar manner as for 5a in 73% yield from 3'-deoxyinosine (1b). Conversion of these AICA derivatives (5a, b) into 3-deazapurine derivatives (9a, b, 15a, b, 20a, b) is also described.
View MoreContact:--
Address:80G, No.1 Building, Guodu Development Mansion, No. 182 Zhaohui Road, Hangzhou City, Zhejiang Province,China.
Shanghai PotentPharm Science and Technology Co.,Ltd
Contact:86-021-51969655
Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
website:http://www.sdowchem.com
Contact:86-135-2193 7483
Address:8-106 taiyue building
Jiaozuo Zhongwen Trading Coporation Limited
Contact:--
Address:East Renmin Road
Chengdu Green technology Co.,Ltd.
Contact:86-28-82608355
Address:C9 ,Economic Headquarters, Economic Development Zone, Chengdu.
Doi:10.1002/jhet.19
(2009)Doi:10.1021/jo9602534
(1996)Doi:10.1134/s1070363208020072
(2008)Doi:10.1007/BF00925632
()Doi:10.1016/S0960-894X(98)00323-0
(1998)Doi:10.1039/a803394c
(1998)
