Enantioselective synthesis of curacin A. 1. Construction of C1-C7, C8-C17, and C18-C22 segments

Article abstract of DOI:10.1016/0040-4039(96)00030-5

Total synthesis of curacin A, a novel antimitotic antiproliferative antibiotic, was achieved by the connection of C1-C7, C8-C17, and C18-C22 segments. Enantioselective preparation of each segments were accomplished by asymmetric allylation, chiral synthon method, and asymmetric hydrolysis by using pig liver esterase, respectively.