Diastereo- and enantio-selective synthesis of 6-heterosubstituted-3,5-dihydroxyesters: Novel precursors of mevinolin analogues

DOI: 10.1039/cc9960000609

Source and publish data:

Chemical Communications p. 609 - 610 (1996)

Update date:2022-08-03

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Authors:

Enders, Dieter

Burkamp, Frank

Runsink, Jan

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Article abstract of DOI:10.1039/cc9960000609

The diastereoselective addition of 1,3 -bis(trimethylsilyloxy)-1-methoxybutadiene 2 to readily available α-heterosubstituted aldehydes (S)-1 affords after syn-diastereoselective reduction HMG-CoA-reductase inhibitor-precursors (S,R,S)-4 and 5 with various

Full text of DOI:10.1039/cc9960000609

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