Synthesis of highly functionalized γ-lactam derivatives for use as conformational constraints in peptides

Article abstract of DOI:10.1016/0040-4039(96)00296-1

A series of highly functionalized 2-oxopyrrolidine derivatives, as tripeptidemimetics in which the amino acid side chains are mounted on the γ-lactam template, were synthesized by nucleophilic opening of the δ-lactam system of the corresponding 3,6-dioxopyrrolo[1,2-a]pyrazine bicyclic analogues.