Construction of an advanced taxane synthesis intermediate with an oxygenated B-ring and a non-aromatic C-ring through intramolecular pinacol coupling at C-1 - C-2

Article abstract of DOI:10.1016/0040-4039(96)00285-7

Advanced taxane synthesis intermediate 4 is available through a thirteen-step sequence wherein the key step is a stereoselective intramolecular pinacol coupling that joint C-1 - C-2 within the eight-membered B-ring.