5(N-methylbenzoylamino)-2,2,6,6-tetramethylheptan-3-ol as a new class of recoverable chiral auxiliary

Article abstract of DOI:10.1016/0040-4039(96)00137-2

Reduction of α-ketoesters bearing 5(N-methylbenzoylamino)-2,2,6,6-tetramethylheptan-3-ol as a chiral auxillary proceeds with high diastereoselectivity by using DIBAL as a reducing agent. The chiral auxiliary is recovered upon treatment with base, and α-hy